CHFR encodes a cell cycle (G2/M) checkpoint, which was suggested to be a tumor suppressor gene28; methylation of CHFR was associated with noninvasive colorectal cancer29, esophageal carcinoma30, hepatocellular carcinoma31, higher grade gastric cancer32 and non-small cell lung carcinoma33. This evidence concerns the gene CHFR and neoplasm.