Some propose that NSAIDs usage upregulates ACE2 expression, thus promoting SARS-CoV-2 entry while other studies demonstrate that NSAIDs have no impact on ACE2 expression and will not exacerbate infection.408–411 There are also concerns that NSAIDs could exacerbate hypercoagulation and the incidence of thrombosis due to decreased thrombomodulin caused by NSAID treatment.412,413 Furthermore, NSAIDs may predispose patients to gastrointestinal and cardiovascular complications which are also canonical symptoms of COVID-19.414. This evidence concerns the gene ACE2 and COVID-19.