SARS-CoV-2 spike protein pseudovirus markedly enhanced the procoagulant ability of tissue factors, while inhibition or silencing ASM attenuated SARS-CoV-2 pseudovirus-induced tissue factor activation.308 Given that ASM activation plays dual roles in both viral entry and pathogenesis, ASM inhibitions are supposed to alleviate COVID-19 severity.309. The gene discussed is SMPD1; the disease is COVID-19.