The 17q21.31 locus contains eight overlapping protein-coding genes, including MAPT, KANSL1, ARL17B, NSF, WNT3, LRRC37A, ARL17A and LRRC37A2. PPI analysis showed that the respective proteins form an interconnected network (Figure 3A), which is functionally linked to a set of diseases associated with cognitive decline (SNEA results). This evidence concerns the gene ARL17A and Mental deterioration.