Tissue array results revealed higher levels of VEGF-C expression in patients with higher-grade ESCC than in those with lower-grade disease (Figure 2E); Figure 2F shows significantly higher levels of VEGF-C expression in the higher-stage tumors (IIB and IVA) than in the lower-stage tumors (IB and IIA) and normal tissue samples. This evidence concerns the gene VEGFC and esophageal squamous cell carcinoma.