CD4 and cancer: CLDN5 expression was linked with an abundance of infiltrating immune cells in eight cancer types, CD4+ T cells in 30 different cancer types, CD8+ T cells in 19, macrophages in 26, neutrophils in 19, and DCs in 22 types of cancer (Figure 5), including COAD, HNSC, kidney renal clear cell carcinoma (KIRC), and LIHC (Figure 5).