SCN8A and epilepsy: Indeed, individuals with a LOF SNV in SCN8A/SCN2A, the genes encoding NaV1.6/NaV1.2, also exhibit epilepsy (Blanchard et al, 2015; He et al, 2019; Meisler, 2019; Johannesen et al, 2022), and the concept that impaired inhibitory neuronal excitability results in epilepsy has been considered in the related disorder of FGF13, a member of the FGF homologous factor family (Puranam et al, 2015).