Since NaV1.2 and NaV1.6, which interact with FGF12, are localized in the central nervous system and are expressed not only in excitatory but also in inhibitory neurons, impairing their neuronal excitability by the effect of FGF12 LOF on NaVs may result in an imbalance of excitatory and inhibitory neuronal activities, eventually leading to epilepsy. This evidence concerns the gene SCN8A and epilepsy.