Deletion of the Adnp in mice leads to compromised brain formation and embryonic lethality,24 and mutations in ADNP underlie the complex neurological and developmental disorder ADNP syndrome (Helsmoortel-Van der Aa autism syndrome, ADNP-related disorder).25 The gene discussed is ADNP; the disease is ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder.