The enriched terms that CD22 mediated B cell receptor (BCR) regulation, Fcγ receptors activation, role of LAT2, NTAL, and LAB on calcium mobilization, scavenging of heme from plasma, creation of C4 and C2 activators, antigen activates BCR leading to generation of second messengers, role of phospholipid in phagocytosis had shown in 5 cancers and initial triggering of complement had shown in 4 cancers. Here, CD22 is linked to cancer.