Even patients with the same variant can display variable expressivity, as has been observed for patients with the ENST00000307340.8:c.11864G>A (ENSP00000305941.3:p.Trp3955Ter) variant in USH2A, with individuals exhibiting a broad range of disease manifestations in later life, ranging from good central vision to severe blindness (117). This evidence concerns the gene USH2A and Blindness.