For example, variants in FGFR1 are known to be associated with encephalocra-niocutaneous lipomatosis (7), Hartsfield syndrome (91), hypogonadotropic hypogonadism (25), osteoglophonic dysplasia (106), and Pfeiffer syndrome (73). Here, FGFR1 is linked to hypogonadotropic hypogonadism.