F2 and neoplasm: On the other hand, it cannotbe entirely excluded that improvement and enrichment of the activityof the original parent Pt(II) complex 1 are achievedwithout the release of free DCF molecules from the Pt(IV) complexes.This multifactorial mechanism of action, affecting a number of differentbiological/biochemical pathways and processes, may represent a greatadvantage as it is very difficult for tumor cells to develop resistanceagainst so many different mechanisms acting simultaneously.