CDH1 and gastric adenocarcinoma: The induction of carcinogenic cascades via the E-cad/β-cat axis was reported in gastric adenocarcinoma associated with Helicobacter pylori infection, in which the bacterium activates calpain sheddase [65], or in myeloid-cell dependent distal colon tumorigenesis associated with Bacteroides fragilis toxin, a known bacterial sheddase [66,67].