HSPB1 and neoplasm: HSPB1, which shows high mean in the tumor region and high variance primarily in the adjacent healthy and the stroma region of the H&E image, is strongly associated with tumor metastasis and metastatic colonization (Blackburn et al. 1997, Lemieux et al. 1998, Bausero et al. 2004, Gibert et al. 2012, Nagaraja et al. 2012).