To study whether Que resets the stem cell niche to a favorable environment for HF growth, we performed a receptor-ligand analysis between cycling HF subpopulations and major niche cells, including FB, EC, LC, SM, Mac1, TC, and Mac2, and found that the interactions between HF subpopulations and stromal cells were augmented by Que treatment (Fig. 4A). This evidence concerns the gene LGALS3 and hydrops fetalis.