These genes were mainly enriched in epidermal cells and HF cells, such as BC, UHF, and GL, and widely involved in epithelial cell differentiation (Sfn, Abl2, and Dll1), the MAPK signaling pathway (Phb2, Ccnd2, and Gja1), and the Wnt signaling pathway (Wnt5a, Lef1, and Rspo1) that reported to be associated with anagen onset (Figs. 2D and S2I; Table S3). The gene discussed is RSPO1; the disease is breast cancer.