Interestingly, the effect of Que on the induction of HIF-1α expression has been consistently observed in other cell types; however, their consequence on cell proliferation is cellular context-dependent, for instance, inhibiting cell proliferation in cancer cells and promoting cell proliferation in endothelial cells (Wilson and Poellinger, 2002; Lee and Lee, 2008; Bach et al., 2010; Anand et al., 2011). This evidence concerns the gene HIF1A and cancer.