These TDEGs were associated with cell adhesion (Col1a1, Hes1, and Icam1) and regulation of collagen metabolic process (Col1a1, Col1a2, and Ctsk) and were mostly attributed to FB, indicating the influence of extracellular matrix (ECM) remodeling on early HF development (Figs. 2D and S2I; Table S3). The gene discussed is CTSK; the disease is hydrops fetalis.