In addition, we also found that FNLS-YE1 could efficiently introduce protective alleles in TYK2 (Diogo et al., 2015; Harper et al., 2015)/WDFY4 (Yang et al., 2010; Zhang et al., 2014) and PCSK9/ANGPTL4 (Harper et al., 2015; Stitziel et al., 2016), offering a potential approach to reduce susceptivity for systemic lupus erythematosus (SLE) and familial hypercholesterolemia (FH), respectively. The gene discussed is ANGPTL4; the disease is familial hyperaldosteronism.