As a proof-of-concept experiment, we repurposed FNLS-YE1 for inducing protective alleles in TYK2 and WDFY4 genes that are associated with reduced risk for SLE (Fig. 6B) (Diogo et al., 2015; Yang et al., 2010; Zhang et al., 2014), via A928V (C > T) (Diogo et al., 2015) and R1816Q (G > A) (Yang et al., 2010) conversion, respectively. Here, TYK2 is linked to systemic lupus erythematosus.