In addition, NPPA on 1p36, FES and FURIN on 15q26, ACTN4 on 19q13, and PREX1 on 20q13.13 encode for proteins that are involved in regulating endothelial permeability and leukocyte transmigration.28,29,30,31,32 These findings provide further support to the idea that preeclampsia liability might be modified by alterations in the integrity of the endothelium. Here, ACTN4 is linked to preeclampsia.