Natriuretic peptide hormones regulate blood pressure and kidney function, among their several other effects.44 In addition, mice that lack the expression of atrial natriuretic peptide develop gestational hypertension and proteinuria and, similar to preeclampsia, exhibit impairment in trophoblast invasion and uterine spiral artery remodeling.45,46 Changes in the function or expression level of these genes with several effects in the key mechanisms of preeclampsia could contribute to the multiorgan dysfunction that is characteristic of this pregnancy-related disorder. This evidence concerns the gene NPPA and preeclampsia.