FURIN and hypertensive disorder: Other discovered loci harbor genes NPR3, PLCE1, PZP, TNS2, FURIN, FES, RGL3, ACTN4, and PREX1. The variants near PZP on 12p13 and ACTN4 on 19q13 did not appear to contain any genome-wide significant variants directly contributing to hypertensive diseases or genes associated with hypertensive disorders in close proximity, unlike the other discovered loci for preeclampsia or other maternal hypertension during pregnancy.