Complementary to these observations, Kim et al. (2013) reported that quercetin, which is a polyphenolic compound extracted from red onion and green tea, generates intracellular ROS and induces apoptosis through the inhibition of mTOR via SESN2 in HCT116 and HT-29 colon cancer cell lines. Here, SESN2 is linked to malignant colon neoplasm.