The authors have speculated that increased level of SESN2 inhibits the endoplasmic stress signalling pathway PERK–eIF2α–CHOP following the treatment with cisplatin, doxorubicin and methotrexate, thereby upregulating autophagy in osteosarcoma cells (Tang et al. 2021). The gene discussed is SESN2; the disease is osteosarcoma.