Of interest is that a relatively recent study (Tarancón-Diez et al. 2020) proposed that sporadic dMMR CRC showed weak to relatively weak MLH1 expression, with complete PMS2 loss in 25%, while this was seen in only 8.5% of LS-associated CRC, making relatively weak expression MLH1 staining a possible marker of sporadic dMMR CRC. The gene discussed is MLH1; the disease is colorectal carcinoma.