Considering that gene expression of IDO and HO-1 was detected since the beginning of the H37Rv strain infection and showed their peak at 28 days of infection, the inhibitor 1MT of IDO activity and ZnPp that block HO-1 was administrated during the second and third week of infection, and mice were euthanized at 2 months of infection. Here, IDO1 is linked to infection.