Recently there was reported the importance of homeostasis of Treg cells and platelets via CD40L-CD40 and PSGL1-P-Sel interaction, the interruption of these pathways leads to hyperinflammation (Rupp et al., 2021), which partially can explain the excessive inflammatory response when Tregs cells were depleted during infection with hypervirulent MTB strain. Here, CD40 is linked to infection.