GRM5 and Anxiety: Although, previous studies emphasize the role of NMDAR hypofunction specifically on PV+ interneurons in reduced sociability (Saunders et al., 2013; Cao et al., 2022), the contribution of mGluR5 and GAD1 co-expressing cells within nodes of SDMN may underlie the comorbidity between social deficits and anxiety-like behaviors, observed in the present study.