Our results revealed that MK-801-treated zebrafish displayed significantly increased density of IL-1β positive cells within the region of interest (ROI) in Dm [t(8) = −5.946, p ≤ 0.001], PM [t(8) = −4.886, p = 0.001], and SRF [t(8) = −4.406, p = 0.008] compared to control group (Figure 6G), suggesting that excessive IL-1β expression within the SDMN, may be associated with social withdrawal behavior and increased anxiety levels. The gene discussed is IL1B; the disease is Anxiety.