The mPFC pyramid neurons regulate the spatial working memory 78, and the initiation of triggering receptor expressed on myeloid cell-2 (TREM2) transcription by activation of nuclear factor erythroid 2-related factor 2 (Nrf2) increases the microglial M2 phenotype in the mPFC, thus ameliorating depression-like behavior 79. The gene discussed is TREM2; the disease is major depressive disorder.