In addition, miR-451a upregulation partially rescued the decreased sucrose preference (Figure 3H) and social preference and social memory in the three-chamber test (Figure 3F, G), without affecting immobility time in the forced swimming test (Figure 3I) or anxiety-like performance in the open field and elevated plus maze of the APP/PS1 mice (Figure S5E-H). The gene discussed is PSEN1; the disease is Anxiety.