CASP3 and cancer: We administered cisplatin (Cis, 7.5 mg/kg), 5-fluorouracil, (5-FU, 150 mg/kg), and paclitaxel (PTX, 115 mg/kg) to mice at dosages within the range used for cancer treatment 29, and examined the changes in the number of Ki67+ proliferative cells and cleaved Caspase 3/6+ apoptotic cells in the circumvallate papilla at Day 3 post injection.