Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1), a NOX4 cytosolic regulator, mediates LPS-induced H2O2 generation through the formation of a ternary complex of p22 (phox)-SH3YL1-NOX4, which ultimately leads to AKI 19. Here, NOX4 is linked to acute kidney injury.