TCRβ-/- mice transferred with CD4-Vehicle T cells developed DSS-induced typical colitis disease, characterized by the pathological features of colitis, including weight loss, increased DAI score, colonic shrinkage, epithelial cell damage, goblet cell loss, crypt swelling and destruction, and inflammatory cell infiltration observed by HE staining (Figure 5D-G). The gene discussed is CD4; the disease is colitis.