TLR4 and neoplasm: Among the target genes, Signal transducer and activator of transcription 3 (STAT3), transcription factor forkhead box O1 (FOXO1), Toll-like receptor 4 (TLR4) and transcription factor forkhead box O3 (FOXO3), which are involved in immune regulation and tumor cell growth and metabolism, are the most closely connected (Figure 5B).