Among the target genes, Signal transducer and activator of transcription 3 (STAT3), transcription factor forkhead box O1 (FOXO1), Toll-like receptor 4 (TLR4) and transcription factor forkhead box O3 (FOXO3), which are involved in immune regulation and tumor cell growth and metabolism, are the most closely connected (Figure 5B). Here, FOXO3 is linked to neoplasm.