In addition, human neutrophil peptide-1 (HNP1) (Li et al., 2014), through the formation of a ternary complex with fibronectin and α5β1 integrin, further inhibits VEGF-induced endothelial cell proliferation, thereby making VEGF-mediated angiogenesis impossible, and ultimately promoting the normalization of tumor microvascular. This evidence concerns the gene VEGFA and neoplasm.