Amplification of the PHGDH gene was identified in several cancers including breast cancer and melanoma, leading to corresponding enzyme overexpression, and decreased PHGDH expression impaired flux into serine synthesis and cell proliferation (Locasale et al., 2011; Mullarky et al., 2011; Possemato et al., 2011). This evidence concerns the gene PHGDH and breast cancer.