mTOR is frequently activated in human cancer, and activated mTORC1 phosphorylates and activates downstream effectors p70S6K and the eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4EBP1) to initiate protein translation/synthesis (Cornu et al., 2013; Sanli et al., 2014). The gene discussed is EIF4EBP1; the disease is cancer.