The correlation analysis for differential biomarkers and microbes found that Lactobacillus_johnsonii_FI9785 were negatively correlated with the differential biomarkers [cholesterol, LysoPA(0:0/18:1(9Z)], Sulfolithocholylglycine and 3a,7a-Dihydroxy-5b-cholestane) associated with the pathogenesis and progression of cholestasis caused by FXR knockout. The gene discussed is NR1H4; the disease is cholestasis.