AHR and steatosis: Moreover, an endogenous AhR agonist derived from a tryptophan catabolism pathway – kynurenine induced hepatic Cyp1b1 and Scd1 expression and resulted in hepatosteatosis [89], whereas inhibition of AhR activity with α-naphthoflavone showed attenuation of steatosis in both high-fat diet fed in vivo and oleic acid-treated HepG2 models of NAFLD.