Similar to the anti-steatotic properties exhibited by the whole body and inducible hepatocyte-specific AhR conditional knockout mice, knockout of the AhR in preadipocytes protected mice from high-fat diet induced obesity and liver steatosis suggesting a role for AhR in adipose tissue and possible cross-talk with liver [85]. The gene discussed is AHR; the disease is obesity due to melanocortin 4 receptor deficiency.