AHR and Hepatic fibrosis: Nevertheless, this was the first in vivo observation that the deficiency of AhR results in hepatic fibrosis and a host of other pathological conditions including failure of developmental closure of the ductus venosis [58], cardiac hypertrophy and fibrosis [59–62], impaired fertility, stunted postnatal growth, multi-organ dysregulation of organogenesis during in utero development, higher risk of embryonic death [63–66], altered mammary gland development [67,68], decreased barrier function [69], immune dysfunction [70–72], oculomotor deficiencies and neuronal function disorders [73,74].