AHR and metabolic disease: Moreover, endogenous AhR agonists generated from the host metabolism (kynurenine, cinnabarinic acid, tryptamine, 6-formylindolo(3,2-b)carbazole, bilirubin) and detected in their commensal microflora (indole-3-carbinole, indole-3-acetic acid, indole[3,2-b]carbazole 7-ketocholesterol) have been identified and extensively studied to understand pathophysiological role of AhR signaling in various metabolic disorders [50–52].