COX4I1 and hereditary elliptocytosis: Oxidative genes (acadm, cpt1a, and pparab) and mitochondrial respiratory complex subunits genes (ndufa9a, sdha, uqcrc2b, cox4i1, and atp5f1b) were significantly reduced in the H group compared to in the N group, while swimming exercise remarkably alleviated this reduction in the HE group (Figures 4I, J).