Males with CAH may experience primary hypogonadism due to testicular damage caused by TARTs or secondary hypogonadism (hypogonadotropic hypogonadism) due to suppression of LH by adrenal T as well as adrenal androgens that have been aromatized to estrone or estradiol. The gene discussed is PLOD1; the disease is Hypergonadotropic hypogonadism.