Males with CAH may experience primary hypogonadism due to testicular damage caused by TARTs or secondary hypogonadism (hypogonadotropic hypogonadism) due to suppression of LH by adrenal T as well as adrenal androgens that have been aromatized to estrone or estradiol. This evidence concerns the gene PLOD1 and hypogonadotropic hypogonadism.