Micro PET studies of [18F]AlF-NOTA-ADH-1 were performed on nude mice bearing pancreatic PDX, Human Colorectal Carcinoma SW480, and pancreatic BxPC3 tumor xenografts at 60 min p.i. A significantly increased radioactive uptake of tumor tissue was shown in the PDX tumor model, with a tumor/muscle ratio of 8.069±2.832. The gene discussed is ADH1A; the disease is colorectal carcinoma.