CDH2 and familial pancreatic carcinoma: However, the pancreatic cancer BxPC3 cells showed no significant increase in fluorescence uptake in tumor tissues at different concentration intervals from 5 μM to 200 μM, presumably due to the low N-cadherin expression in pancreatic cancer BxPC3 cells, which was confirmed by in vivo N-cadherin immunohistochemical staining in nude mice.