SIRPA and non-small cell lung carcinoma: Recently, a fusion protein of CBD and the Fc of SIRPα (signal regulatory protein α) (423), which targets the SIRPα-CD47 axis, showed accumulation in the tumor tissue, more antitumor activity and an increase infiltration of M1-like macrophages than SIRPα Fc alone, in a xenograft model of NSCLC (424).