SOD3 and neoplasm: One example of molecules that stimulate cell extravasation is the extracellular superoxide dismutase 3 (SOD3), an enzyme expressed within the TME that improves the aberrant functions of tumor-associated vasculature by stabilizing hypoxia-inducible factor 2 (HIF2α) that, in turn, induces the expression of vascular endothelial cadherin (212, 217).