Similarly, DSP with a panel of 39 markers has also been applied to evaluate the expression of immune-related proteins, including MHCII, in the tumor epithelium of TNBC compared to their expression levels in the stromal compartment; higher HLA-DR levels are present in the tumor epithelial cells of patients with long-term disease-free survival and are also associated with high CD4 and ICOS levels in the stromal compartment (120). Here, ICOS is linked to neoplasm.