applied DSP in 24 TNBC tissue samples to quantify and analyze the differential expression of 68 targets in the tumor and TME compartments between responsive and nonresponsive tumors; elevated ER-alpha expression as well as reduced 4-1BB and MART1 expression within the stromal compartment are implicated in the adjuvant chemotherapy response, whereas increased GZMA, STING, and fibronectin levels as well as decreased CD80 levels are associated with the response within the tumor compartment (119). The gene discussed is ESR1; the disease is neoplasm.