IGF1 and colorectal carcinoma: Overall, pooled results from 5 studies (comprising 1,035 cases and 2,726 controls) for IGF1 rs6214C>T, revealed a significant association between the polymorphism and an increased CRC risk in some of the comparisons studied (CC, OR = 0.43, 95% CI 0.21- 0.87, P = 0.019; CT, OR = 0.97, 95% CI 0.64–1.47, P = 0.879; TT, OR = 1.37, 95% CI 0.83– 2.26, P = 0.216) (Figure 2).