For IRS2 rs1805097G>A, pooled results from 5 studies (comprising 5,220 cases and 6,014 controls) revealed a significant association between the polymorphism and an increased CRC risk in some of the comparisons studied (AA, OR = 0.94, 95% CI 0.84-1.06, P = 0.358; GA, OR = 0.83, 95% CI 0.71-0.96, P = 0.013; GG, OR = 0.96, 95% CI 0.84-1.10, P = 0.627) (Figure 4). The gene discussed is IRS2; the disease is colorectal carcinoma.