While direct associations of FGF23 SNP2 or SNP3 with phosphate metabolism have not previously been described, minor allele homozygosity of SNP1 is related to lower phosphate concentrations in adult nephrolithiasis patients and a smaller cohort of school-aged children (Rendina et al., 2012; Pekkinen et al., 2015). The gene discussed is FGF23; the disease is nephrolithiasis.