Subgroup analyses based on ethnicity showed that in the heterozygote model (OR = 0.716, PZ = 0.000), dominant model (OR = 0.752, PZ = 0.000) and allele model (OR = 0.817, PZ = 0.002), EPHX1 rs2234922 was significantly associated with reduced COPD risk among Asians, indicating that the GA genotype may be a protective factor for COPD among Asians. The gene discussed is EPHX1; the disease is chronic obstructive pulmonary disease.