Here, we conducted a systematic review and meta-analysis to determine the association of EPHX1 (rs1051740 and rs2234922) and GSTP1 (rs1695 and rs1138272) polymorphisms with the risk of COPD risk, with the aim of providing evidence-based information on COPD pathogenesis which can be used to develop potential strategies for its diagnosis, prevention and treatment. This evidence concerns the gene EPHX1 and chronic obstructive pulmonary disease.