For the homozygote model (OR = 1.434, PZ = 0.022) and recessive model (OR = 1.395, PZ = 0.000), GSTP1 rs2234922 was found to be significantly associated with COPD risk, indicating that the GG genotype is a risk factor for COPD. This evidence concerns the gene GSTP1 and chronic obstructive pulmonary disease.