In addition, we also found that in the homozygote model (OR = 1.497, PZ = 0.025), dominant model (OR = 1.14, PZ = 0.028), recessive model (OR = 1.482, PZ = 0.033) and allele model (OR = 1.186, PZ = 0.005), EPHX1 rs1051740 was significantly associated with COPD risk among Caucasians, indicating that the CC genotype is a risk factor for COPD in Caucasians. The gene discussed is EPHX1; the disease is chronic obstructive pulmonary disease.