Subgroup analysis based on ethnicity showed that in the homozygote model (OR = 1.453, PZ = 0.007), heterozygote model (OR = 1.465, PZ = 0.027), dominant model (OR = 1.520, PZ = 0.005), and allele model (OR = 1.308, PZ = 0.002), EPHX1 rs1051740 was significantly associated with COPD risk among Asians, suggesting that the C allele is a risk factor for COPD in Asians. The gene discussed is EPHX1; the disease is chronic obstructive pulmonary disease.