As is shown in Figure 2, All Notch receptors (including Notch1, Notch2, Notch3, and Notch4) presented significantly higher expression at mRNA level in GBM tissues than in normal tissues both in TCGA and CGGA databases (Figures 2A, B), suggesting that all Notch receptors might have oncogenic roles in the tumorigenesis and progression of GBM. The gene discussed is NOTCH4; the disease is glioblastoma.