As shown in Figure 3A, Notch1 in Classical and Proneural subtypes of GBM showed significantly higher expression than that in the Mesenchymal subtype, while Notch2 and Notch3 displayed high expression in Classical and Mesenchymal subtypes of GBM and low expression in Proneural subtype. This evidence concerns the gene NOTCH3 and glioblastoma.