We found that GBM patients with the genetic alteration of Notch1 and Notch4 have a shorter median overall survival and median disease-specific survival than the unaltered group, especially Notch3 presented the shortest median overall survival and median disease-specific survival (Figure 1C), suggesting an essential role of Notch receptors in the GBM progression. Here, NOTCH4 is linked to glioblastoma.