They demonstrated that expression levels of MeCP2, a transcription regulator, were higher in NP vs. control ITM and was suppressed by 5-azacytidine, which had an inhibitory effect on TGF beta-1 nasal polyp-derived fibroblasts (NPDFs) and extracellular matrix (ECM) production (25). The gene discussed is MECP2; the disease is Nasal polyposis.