Moreover, top hub genes in this module (Figure 3D) were associated with the development of Alzheimer’s disease, including VSNL1 (Kirkwood et al., 2016), INA (Dickson et al., 2005), CHN1 (Kato et al., 2015), NMNAT2 (Ljungberg et al., 2012), and MAP7D2 (Khundakar et al., 2016). The gene discussed is CHN1; the disease is early-onset autosomal dominant Alzheimer disease.