Further comparison of the subpopulations observed in the healthy volunteer, sep-ARDS patients, and the PNE-ARDS patient showed that CD8+ T_LTB cells were less abundant in sep-ARDS patients and the PNE-ARDS patient and CD8+ T_ITGB2, CD8+ T_CCR7, and CD8+ T_GZMK were more abundant in sep-ARDS patients, while CD8+ T_NKG7 and CD8+ T_MKI67 were more abundant in the PNE-ARDS patient, relative to the control (Figure 2C). This evidence concerns the gene CD8A and acute respiratory distress syndrome.