In addition to this, the GRN, with transcription factors (TFs) as the fulcrum, was organized into three modules (Figure 2G), directing cell fate selection by regulating specific gene expression of ARDS-specific CD8+ T cells through TFs such as NKX3-1, EGR1, ETV1, RUNX3, and CLOCK (Figure 2H). This evidence concerns the gene RUNX3 and acute respiratory distress syndrome.