Further comparison of the cell composition among control, sep-ARDS, and PNE-ARDS revealed that the dynamics of neutrophils, macrophages (Macs), classical dendritic cells (cDCs), myeloid-derived suppressive cells (MDSCs), and CD8+ T cells varied significantly among groups of different samples, with neutrophils and cDCs being more abundant and Macs significantly less abundant in sep-ARDS patients; MDSCs were highly enriched only in sep-ARDS, and CD8+ T cells were more abundant in PNE-ARDS (Figure 1D). The gene discussed is CD8A; the disease is acute respiratory distress syndrome.