Among them, M2 is the phenotype that exerts suppressive inflammatory overreaction and negative immunomodulatory effects, which can be polarized into M2a, M2b, M2c, and M2d subtypes when stimulated by IL-4/IL-13, LPS/immunocomplexes, IL-13/TGF-β, and tumor-associated factors, respectively (Lu et al., 2013; Murray, 2017; Arora et al., 2018; Orecchioni et al., 2019). This evidence concerns the gene IL4 and neoplasm.