In reciprocal experiments, increasing plasma MIF concentrations in a mouse model, overexpressing MIF in lung (Mif lung Tg mice (Mif Tg)), demonstrated that high circulating MIF levels (Figure 1U) are associated with IR and hypertriglyceridemia in the absence of alterations in inflammatory gene expression in adipose tissue (Figures 1V, 1W, and S7). Here, MIF is linked to hypertriglyceridemia.