All cytokines examined in table 3.3, including IFN-γ (76.29±6.74), CCL3 (1856.82±190.66), IL-13 (16677.32±4080.45), Collagen IVα1 (2135.63±893.25), and TIMP-1 (117774.75±7485.08) revealed statically significant increase among participants in the CDI group and control group who received chemotherapy before study treatment (p = 0.02, 0.03, 0.04, 0.04, & 0.00). Here, TIMP1 is linked to clostridium difficile infection.