Our further investigation elucidated that in the early tumor stage (I/II), low grade (I/II), median or well tumor differentiation, small tumor size (less than 5cm), and low alpha-fetoprotein (AFP) level subgroups (<400ng/ml), higher HCFC1 protein level patients both have shorter OS (Figure 3A-C, G-H) and RFS (Figure 3D-F, J-K) period than patients with lower HCFC1 protein expression (Figure 3). The gene discussed is HCFC1; the disease is neoplasm.