U2AF1 and Wilms tumor: Therefore, it is reasonable to believe that the WDR4 rs6586250 C > T polymorphism is likely to alter Wilms tumor susceptibility by affecting the expression of nearby genes U2AF1 and CBS. Overall, we speculate that the WDR4 rs6586250 T allele may increase the risk of Wilms tumor by upregulating WDR4 gene expression or altering the expression of the surrounding genes U2AF1 and CBS. However, the exact mechanism of how WDR4 gene SNPs contribute to Wilms tumor susceptibility remains unclear.