The complex directly methylated a series of tumor-suppressive miRNAs, particularly the let-7e family, and promoted the maturation of let-7e miRNAs; these miRNAs in return downregulated specific oncogenes such as high-mobility group AT-hook 2 (HMGA2), thereby suppressing the migration ability of lung cancer cells 21. Here, HMGA2 is linked to neoplasm.