Although the observed effects were only moderate in comparison to well-known neutrophil chemoattractants, such as IL-8 or bacterial-derived stimuli such as fMLP (N-Formylmethionyl-leucyl-phenylalanine), our findings suggest an enhancing effect of endostatin on the inflammatory environment during ARDS (33). This evidence concerns the gene CXCL8 and acute respiratory distress syndrome.