CD4 and myeloid sarcoma: The adiponectin hormone secreted by adipose tissue was found to be significantly abundant within the serum of children with MS (n=43, p<0.005) and appears to induce pro-inflammatory states of CD14+ monocytes through increased expression of CD80, CD86, TNF-α and IL-6, as well as the adaptive immune cells IFN-γ producing CD4+ and CD8+ T cells directly or via myeloid cells, and altering the quiescence profile of human microglia (92).