In SLE patients, Vitamin A treatment increased antibody-dependent cellular cytotoxicity (ADCC) functions in effector to target cells (p<0.001), NK cell cytotoxicity measured using Cr-labeled K-562 target cells (p<0.001), and IL-2 activities measured in PBMC treated with concanavalin A (p<0.001), while decreasing anti-dsDNA and proteinuria in lupus nephritis (367, 368). This evidence concerns the gene IL2 and systemic lupus erythematosus.