At the cellular level, MS represents an abnormal balance between effector and regulatory T cells, including aberrant pro-inflammatory functions of IFN-γ+ TNF-α+ CXCR3+ Tbet+ Th1, IL-17+ CCR6+ CD161+ RORγt+ Th17 and GM-CSF+ T cells (44), while IL10+ CD25high CD127- FOXP3+ Tregs present deficient functions. Here, TNF is linked to myeloid sarcoma.