85% significant increase risk to develop SLE in obese women compared to those with healthy BMI (22)Obesity at age 18 is associated with double SLE incidence during adulthood (HR 2.38, 95% CI:1,26-4.51) (23)Increased pro-inflammatory markers IL-6, IL-23, TNF-α & C-reactive protein (CRP) (24) known to be elevated in SLE and produced by adipose tissue.SLE patients harbor elevated serum resistin levels (p<0.001) that correlate with renal dysfunction and proinflammatory markers (25). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.