In MS, Th17 are recognized to be pathogenic T cells, and Kleinewirtfeld et al., further showed that in vitro 40nM of NaCl promotes the pro-inflammatory pathogenic Th17 IL-17+, through the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and the nuclear factor of activated T cells 5 (NFAT 5) (120). This evidence concerns the gene IL17A and myeloid sarcoma.