̃3% weight increase in MS cases (n=1571) compared to controls (n=3371) (15)Significant 1.61-1.95 fold increased risk of MS associated with higher body mass index (BMI) in a cohort of (n=302,043) children (16)Adult GWAS data (n=32,105) identified 70 distinct SNPs related to genetically high BMI as a risk to develop MS (17)Expansion of adipocytes, a source of pro-inflammatory cytokines IL-6, TNF-α, in turn, help recruit immune cell infiltrates (18, 19)High resistin levels correlate with higher BMI, EDSS and IL-1β and TNF-α (20, 21). Here, RETN is linked to myeloid sarcoma.