CD4 and systemic lupus erythematosus: Physical activity such as Tai Chi Chuan promotes a healthy immune state by significantly increasing the ratio T helper to suppressor cells (CD4:CD8) (p=0.05), and increasing CD4+CD35+ Tregs producing TGF-β and IL10 known to suppress the immune system (195, 196).Thus, physical hypoactivity can exacerbate adipose-related systemic inflammation (197) and exercise may be an area of intervention for SLE patients.