Another study has shown that GLP-1/GLP-1R signaling in macrophages suppresses M1 polarization and triggers M2 polarization (68).In light of these findings, we speculate that GLP-1 alleviates obesity-related inflammation via inhibiting macrophage recruitment and promoting M2 macrophage polarization in AT. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.