SOCS3 and colitis: To assess the function of Socs3 in myeloid cells in the pathogenesis of colitis, Socs3fl/fl mice crossed with LysM-Cre mice (Socs3ΔLysM), which leads to deletion of Socs3 in myeloid cells, including macrophages, neutrophils and partially in dendritic cells, were used (43, 44).