AKT1 and neoplasm: These findings are consistent with the fact that biotoxins such as bee venom, snake venom, toad venom, and scorpion venom can promote tumor cell apoptosis and reduce tumor size by inhibiting tumor angiogenesis by inhibiting the activation of phosphatidylinostat 3-kinase (PI3K) and phospho-Akt (p-Akt) (25–32).