For example, NLRP3 inflammasome activation has been shown to be involved in Alzheimer’s disease (triggered by amyloid β aggregates (14, 54)), atherosclerosis (triggered by cholesterol crystals (55)) and asbestosis (triggered by asbestos particles (6)), and whether C4BP can inhibit NLRP3 inflammasome signalling by these activators should be formally investigated in future studies. This evidence concerns the gene NLRP3 and atherosclerosis.